Genetics of the genomes within us
Online
Thursday 3rd December 2026 1:30PM
Presentation by Po-Ru Loh
| Abstract: Over the past several years, biobank sequencing studies have rapidly accrued whole-genome sequencing data from millions of human biosamples. While primarily intended to capture inherited human genetic variation, these data sets also contain abundant, yet subtle signals of acquired (somatic) variation, including recurrent DNA repeat expansions and chromosomal alterations. Additionally, whole-genome sequencing captures small amounts of microbial and viral DNA present in saliva and blood. I will describe how analyzing such DNA phenotypes together with inherited genetic variation can provide insights into the biological mechanisms that regulate these phenomena as well as their impacts on human health. Bio: Po-Ru Loh leads a statistical genetics research group in the Division of Genetics at Brigham and Women's Hospital and Harvard Medical School. His lab develops efficient computational tools for exploring genetic effects on complex traits in biobank cohorts. In recent years, he and his lab have focused on studying germline and somatic structural variants, including copy-number variants, tandem repeats, and mosaic chromosomal alterations. His work has been recognized with an NIH New Innovator Award, a Sloan Research Fellowship, and the ISCB Overton Prize. |
| Topic: HDR UK Cambridge Seminar Series - Po-Ru Loh Time: Dec 3, 2026 01:30 PM London https://cam-ac-uk.zoom.us/j/83183046253?pwd=Vzsm7gTDy8g4Y3BDEy9O9gHqYUkaCt.1 https://cam-ac-uk.zoom.us/launch/jc/83183046253 Passcode: 659508 |
Event Details
Join us at the HDR UK Cambridge Seminar series - 3 Dec 2026 at 13:30
Starts at 1:30PM
